Let KAYAK do the searching
Based on KAYAK hotel searches, the most popular destination is Uyuni (33% of total searches to Bolivia). The next most popular destinations are Santa Cruz de la Sierra (33%) and La Paz (17%). Searches for hotels in Sucre (17%) are also popular.
Based on KAYAK hotel searches, the most popular region to stay in Bolivia is La Paz. Santa Cruz and Chuquisaca are also very popular.